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KMID : 0361120030170010015
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Korean Journal of Transplantation
2003 Volume.17 No. 1 p.15 ~ p.19
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Implantation of Renal Segments on Biodegradable Polymer Scaffolds
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김상수/Sang Soo Kim
박흥재/한정호/최차용/김병수/Heung Jae Park/Joung Ho Han/Cha Yong Choi/Byung Soo Kim
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Abstract
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PURPOSE: Dialysis and renal transplantation, the current therapies for end-stage renal disease (ESRD), have limitations including severe complications, donor organ shortage, and allograft failure. The present study investigated the possibility of using
a tissue engineering technique for renal reconstruction as a new method to replace the current suboptimal treatments for ESRD. We reconstituted renal units in vivo by transplanting isolated renal segments on three-dimensional, biodegradable polymer
scaffolds. METHODS: Renal segments were freshly isolated from Sprague- Dawley rat kidneys and seeded onto porous mesh matrices fabricated from polyglycolic acid, a biodegradable synthetic polymer. The renal segment-seeded scaffolds were implanted into
subcutaneous spaces of athymic mice for two and four weeks. Retrieved specimens were examined by histological analyses. RESULTS: The tubular structures with hollow centers and vascular tufts of glomerulus-like structures were identified by histological
analyses of the 2 and 4 week specimens. In contrast, no renal-like structures were observed from unseeded polymer implants (negative controls). CONCLUSION: These results suggest a possibility of reconstituting the renal structures by transplanting renal
segments on polymer scaffolds and could be applid for partial or full replacement of kidney function in the treatment of ESRD.
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KEYWORD
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